Average locus differences in mutability related to protein "class": a hypothesis.
نویسندگان
چکیده
منابع مشابه
Evaluation of gender-related differences in response to oxidative stress in toxoplasma gondii positive serum
Purpose: Toxoplasma gondii (T. gondii) is the causative agent of toxoplasmosis. It infects up to one third of the human population. The aim of this study was to evaluate the effects of T. gondii infection on induction of oxidative stress in serum of infected men and women. Materials and Methods: This case-control study was carried out on 150 individuals who had referred to our center ...
متن کاملNews from the protein mutability landscape.
Some mutations of protein residues matter more than others, and these are often conserved evolutionarily. The explosion of deep sequencing and genotyping increasingly requires the distinction between effect and neutral variants. The simplest approach predicts all mutations of conserved residues to have an effect; however, this works poorly, at best. Many computational tools that are optimized t...
متن کاملTheory for protein mutability and biogenesis.
Using an elementary physical model for protein folding, of self-avoiding short copolymer chains on two-dimensional square lattices, we address two questions regarding the evolution and origins of globular proteins. (i) How will protein native structures and stabilities be affected by single-and double-site mutations? (ii) What is the probability that a randomly chosen sequence of amino acids wi...
متن کاملA cDNA encoding tyrosinase-related protein maps to the brown locus in mouse.
A mouse melanoma cDNA clone was isolated by virtue of its reactivity with two antisera raised against tyrosinase (EC 1.14.18.1) from two species, hamster and mouse. The cDNA (5A) cross-hybridizes with another, pMT4 [Shibahara, S., Tomita, V., Sakakura, T., Nager, C., Bhabatosh, C. & Muller, R. (1986) Nucleic Acids Res. 14, 2413-2427], previously thought to encode mouse tyrosinase. Two other cDN...
متن کاملIndividual Differences 1 Running head: INDIVIDUAL DIFFERENCES IN MATHEMATICS Determining the Locus of Individual Differences in Mathematical Skill: A Tri-level Hypothesis Approach
In this paper, I address the pervasive phenomenon of individual differences in basic mathematical skill among adults. Within the framework outlined by Marr (1982), differences in mathematical skill must reflect differences at one or more of the following levels: computational theory (mapping), choice of representation and algorithm (solution procedure), or hardware implementation (brain). Resea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1990
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.87.6.2062